George, Lizzie, and Ralph have been captured and confined for the world to see. George is held captive in New York City, Lizzie is imprisoned in Tokyo, and Ralph is stored in London (references to King Kong, Godzilla, and Werewolf of London (or An American Werewolf in London, respectively). However, Scumlabs, who has just rebuilt their facilities in Salt Lake City, causes another accident that results in three new monsters: Boris, a rhinoceros, Curtis, a mouse, and Ruby, a lobster.