The main story follows the characters being affected with a series of events that foreshadow the merging worlds of both Puyo Puyo and Tetris. Similar to Puyo Puyo 7, the story is divided into seven acts, with ten playable episodes. These episodes consist of different game modes, which may be played with or without an opponent. However, playable characters are locked, meaning the player can only use the character relevant to that part of the story, including characters that have not yet unlocked.