The game's story begins when The Nameless One wakes up in a mortuary. He is immediately approached by a floating skull, Morte, who offers advice on how to escape. Morte also reads the tattoos written on The Nameless One's back, which were inked there as reminders to himself, that contain instructions to find a man named Pharod. After a conversation with the ghost of his former lover, Deionarra, and passing by various undead, The Nameless One leaves the mortuary to explore the slums of Sigil.