In the war-torn Japan of the late 1500s, a half-yokai known as a Shiftling can channel demonic power drawn from both a human father and a yokai mother. Drawn into the turmoil of the Sengoku era, the Shiftling befriends Tokichiro, an ambitious merchant chasing the mystical substance Amrita, and Mumyo, a steadfast demon hunter. Together they wade into the rise and fall of warring clans and warlords while facing hordes of yokai across the land. Shadowing their every step is the enigmatic Kashin Koji, a sinister figure tied to an ancient demon who manipulates events from behind the scenes.