Set some time after Guybrush Threepwood's first adventure, the story follows him as he searches the islands for a legendary treasure known as Big Whoop. His efforts accidentally lead to the return of the zombie pirate LeChuck, who vows revenge against him. With guidance from the Voodoo Lady, Guybrush learns that a map to Big Whoop was split into pieces and scattered, and he travels between several islands to gather them while staying ahead of his vengeful enemy.