When Doctor Doom unites the Marvel Universe's most dangerous villains into a group called the Masters of Evil and strikes at S.H.I.E.L.D., Nick Fury sends out a call for help. Heroes from across the Marvel world answer, banding together into a single task force to meet the growing threat. As Doom's scheme for global domination unfolds, the alliance of heroes must track his forces across many battlegrounds. Their mission is to stop him before his plans reshape the fate of the world.