Set in the American Old West, specifically Arizona, Colorado, Kansas and New Mexico in the year 1880, Colton White and his father Ned are hunting game along the Missouri River and after a close call with a grizzly they board a riverboat to sell meat. But after the riverboat is attacked by murderous preacher Reverend Josiah Reed, in the midst of the chaos Ned reveals to Colton that he is not his biological father, and then tells him to seek out a specific prostitute in Dodge City, prompting Colton White on an adventure of revenge and self discovery.