Duke Nukem takes his Mighty Boot to the Big Apple. Using GLOPP (Gluon Liquid Omega-Phased Plasma), the maniacal mech Morphix has transformed the creatures of New York City into an army of bloodthirsty mutants. In Duke Nukem: Manhattan Project, Duke must deploy WIN (Weapons, Insults and Name-Calling) to rid the city of goo-based bad guys, and return peace and tranquility to The City That Never Sleeps.