The storyline follows the events of the previous game, where Regina is on another mission involving a facility located close to the fictional Edward City, where a major anomaly has caused the whole city to be transported back in time to the era of the dinosaurs, along with all the human inhabitants. Regina is sent on a rescue mission with her new ally Dylan Morton, who has a strange connection to the events on the island. The player switches between controlling Regina and Dylan at specific points in the game.