The heroes must struggle against the evil forces of X.A.N.A which has escalated it's attempts to take over the real world by creating Replika worlds. The only way to stop it is to destroy the Replikas. But the heroes realize that destroying the Replikas is useless unless they destroy the supercomputer linked to it. Changing tactics, they realize they can use "Translation" to materialize in the labs that contain each supercomputer, which are hidden around the globe, protected by bosses. Each end-level boss is a guardian that exists in the physical world, and has been built or enhanced. The heroes must confront all the bosses and destroy all the supercomputers before achieving their ultimate goal of saving William.